Uncoupling Malt1 Threshold Function from Paracaspase Activity Results in Destructive Autoimmune Inflammation
نویسندگان
چکیده
منابع مشابه
Paracaspase MALT1 deficiency protects mice from autoimmune-mediated demyelination.
The paracaspase MALT 1 is a major player in lymphocyte activation and proliferation. MALT1 mediates Ag-induced signaling to the transcription factor NF-κB by functioning both as a scaffold protein and cysteine protease. We studied the role of MALT1 in the development of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis. MALT1-knockout mice did not develop an...
متن کاملMolecular pathways: targeting MALT1 paracaspase activity in lymphoma.
MALT1 mediates the activation of NF-κB in response to antigen receptor signaling. MALT1, in association with BCL10 and CARD11, functions as a scaffolding protein to activate the inhibitor of IκB kinase (IKK) complex. In addition, MALT1 is a paracaspase that targets key proteins in a feedback loop mediating termination of the NF-κB response, thus promoting activation of NF-κB signaling. Activate...
متن کاملMultiorgan Inflammation Effector T and B Cell Responses Leading to Results in Unbalanced Regulatory and Deficiency of MALT1 Paracaspase Activity
Dhavalkumar D. Patel and Thomas Calzascia Catherine H. Régnier, Tak W. Mak, Pamela S. Ohashi, Natasa Zamurovic, Kathy D. McCoy, Antonius Rolink, Traggiai, Dirk Brenner, Anne Brüstle, Michael St. Paul, Weckbecker, Gerhard Zenke, Bernd Kinzel, Elisabetta Katopodis, Barbara Nuesslein-Hildesheim, Gisbert Christoph Burkhart, Janet Dawson, Satoru Niwa, Andreas Paul A. Smith, Marc Bigaud, Ursula Junke...
متن کاملProbes to monitor activity of the paracaspase MALT1.
The human paracaspase mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) plays a central role in nuclear factor-κB (NF-κB) signaling as both a protease and scaffolding protein. Knocking out MALT1 leads to impaired NF-κB signaling and failure to mount an effective immune response. However, it is unclear to which degree it is the scaffolding function versus the proteolytic...
متن کاملMechanism and specificity of the human paracaspase MALT1
The paracaspase domain of MALT1 (mucosa-associated lymphoid tissue lymphoma translocation protein 1) is a component of a gene translocation fused to the N-terminal domains of the cellular inhibitor of apoptosis protein 2. The paracaspase itself, commonly known as MALT1, participates in the NF-κB (nuclear factor κB) pathway, probably by driving survival signals downstream of the B-cell antigen r...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell Reports
سال: 2014
ISSN: 2211-1247
DOI: 10.1016/j.celrep.2014.10.044